[Sar1, Ile8]-Angiotensin II

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The biological activities of angiotensin II antagonists upon basal and angiotensin II-stimulated aldosterone production were evaluated in an isolated canine glomerulosa cell preparation. Our investigations found that the most potent competitive antagonist of angiotensin II-stimulated aldosterone production was the [Sar1, Ile8] derivative of angiotensin II. However, this peptide was also a partial agonist at concentrations required to inhibit the steroidogenic effect of angiotensin II on dog adrenal cells, and never reduced aldosterone production to basal levels.

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Catolog No: N/A Category:

Sequence (One-Letter Code):

Sar-RVYIHPI

 

Sequence (Three-Letter Code):

Sar-{Arg}{Val}{Tyr}{Ile}{His}{Pro}{Ile}

 

Molecular Weight:

968.2

 

Purity:
% Peak Area By HPLC ≥ 95%

 

Salt:
TFA Salt

 

Storage:

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

 

Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

 

Documents:

MSDS

Amount

1 mg, 5 mg, Other