Calcitonin Gene Related Peptide (CGRP) (8-37), human

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Calcitonin-Gene-Related Peptide (CGRP) (8-37) inhibits the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats. The present study was performed to explore the effect of CGRP (8-37) on the electrical stimulation-evoked discharge frequency of wide dynamic range (WDR) neurons in the dorsal horn of the spinal cord in rats. CGRP (8-37) was applied directly on the dorsal surface of the L3 to L5 spinal cord. The results indicate that CGRP receptors play an important role in the transmission of presumed nociceptive information in the dorsal horn of the spinal cord.

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Sequence (One-Letter Code):

VTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2

 

Sequence (Three-Letter Code):

{Val}{Thr}{His}{Arg}{Leu}{Ala}{Gly}{Leu}{Leu}{Ser}{Arg}{Ser}{Gly}{Gly}{Val}{Val}{Lys}{Asn}{Asn}{Phe}{Val}{Pro}{Thr}{Asn}{Val}{Gly}{Ser}{Lys}{Ala}{Phe}-NH2

 

Molecular Weight:

3125.6

 

Purity:
% Peak Area By HPLC ≥ 95%

 

Salt:
TFA Salt

 

Storage:

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

 

Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

 

Documents:

MSDS

Amount

0.5 mg, 1 mg, Other