390 MMP FRET Substrate I

$99.00$305.00

A fluorogenic substrate that is best cleaved by MMP-7, 8, 9 and 13. The highly fluorescent Mca moiety is efficiently quenched by energy transfer to the Dnp group. The punctuated metallo proteinase (PUMP, EC 3.4.24.23) cleaves the substrate at the Gly-Leu bond with a 190-fold increase in fluorescence (Abs/Em = 325/393 nm). In human matrix metalloproteinases assays, this substrate is about 50 to 100 times more sensitive than the generic MMP substrate, Dnp-PLGLWAr-NH2 (Cat# 27074).

Clear
Catolog No: N/A Category:

Sequence (One-Letter Code):

Mca-PLGL-Dap(Dnp)-AR-NH2

 

Sequence (Three-Letter Code):

Mca-{Pro}{Leu}-{Gly}-{Leu}-Dap(Dnp)-{Ala}-{Arg}-NH2

 

Molecular Weight:

1093.2

 

Purity:
% Peak Area By HPLC ≥ 95%

 

Salt:
TFA Salt

 

Storage:

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

 

Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

 

Documents:

MSDS

Amount

1 mg, 5 mg, Other