[Sar1, Ile8]-Angiotensin II
The biological activities of angiotensin II antagonists upon basal and angiotensin II-stimulated aldosterone production were evaluated in an isolated canine glomerulosa cell preparation. Our investigations found that the most potent competitive antagonist of angiotensin II-stimulated aldosterone production was the [Sar1, Ile8] derivative of angiotensin II. However, this peptide was also a partial agonist at concentrations required to inhibit the steroidogenic effect of angiotensin II on dog adrenal cells, and never reduced aldosterone production to basal levels.
Amount:
Catalog No.: N/A
Category: Angiotensins and Related Peptides
Sequence (One-Letter Code):
Sar-RVYIHPI
Sequence (Three-Letter Code):
Sar-{Arg}{Val}{Tyr}{Ile}{His}{Pro}{Ile}
Molecular Weight:
968.2
Purity:
% Peak Area By HPLC ≥ 95%
Salt:
TFA Salt
Storage:
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.