Substance P, Free Acid

$43.00$75.00

The conformation of substance P (free acid) (SPOH) has been investigated in dimethylsulfoxide (DMSO), water and dipalmitoylphosphotidylcholine (DPPC) bilayers by two-dimensional NMR and restraint molecular dynamics simulations. The observed NOE patterns for substance P (free acid) in these media are very much different from each other. The conformation of substance P (free acid) in DPPC bilayers is characterized by gamma-bends at Pro4,Gln6and Phe7, which are stabilized by hydrogen bonding between Lys3CO–>Gln5NH, Gln5CO–>Phe7NH and Gln6CO–>Phe8NH, respectively. The absence of biological activity in SPOH has been attributed to the absence of any helix like structure at the central residues and absence of any interresidue interaction with C-terminal OH group, in DPPC bilayers, a feature shown to be an important prerequisite for SP and SP agonists to bind to the NKI tachykinin receptor.

Clear
Catolog No: N/A Category:

Sequence (One-Letter Code):

RPKPQQFFGLM

 

Sequence (Three-Letter Code):

{Arg}{Pro}{Lys}{Pro}{Gln}{Gln}{Phe}{Phe}{Gly}{Leu}{Met}

 

Molecular Weight:

1348.7

 

Purity:
% Peak Area By HPLC ≥ 95%

 

Salt:
TFA Salt

 

Storage:

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

 

Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

 

Documents:

MSDS

Amount

5 mg, 10 mg, Other